Drusen deposits are typically located in which retinal layer?

Drusen deposits are typically located in which retinal layer?

• A. RPE
• B. Choroid
• C. Nerve fiber layer
• D. Photoreceptor layer

Answer: (A)

Drusen are extracellular deposits that accumulate in the sub‑RPE space, sitting just beneath the retinal pigment epithelium (RPE) at the interface with Bruch’s membrane. Because they reside adjacent to the RPE, the layer that best describes their location is the RPE layer (in the sub-RPE region). The choroid lies behind Bruch’s membrane; the nerve fiber layer and photoreceptor layer are anterior to the RPE. So drusen form in the area directly associated with the RPE, often signaling changes at the RPE–Bruch’s membrane interface.

Drusen are extracellular deposits that accumulate in the sub‑RPE space, sitting just beneath the retinal pigment epithelium (RPE) at the interface with Bruch’s membrane. Because they reside adjacent to the RPE, the layer that best describes their location is the RPE layer (in the sub-RPE region). The choroid lies behind Bruch’s membrane; the nerve fiber layer and photoreceptor layer are anterior to the RPE. So drusen form in the area directly associated with the RPE, often signaling changes at the RPE–Bruch’s membrane interface.